The new dimeric copper(II) complex from anticancer drug cytosine arabinoside
Yazarlar (3)
Dr. Öğr. Üyesi Özge Güngör Türkiye
Doç. Dr. Zeynep KELEŞOĞLU Sinop Üniversitesi, Türkiye
Prof. Dr. Ayşegül Gölcü Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 1270 / 0 / – | DOI | 10.1016/j.molstruc.2022.133826 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2022.133826 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In this study, the new copper(II) based cytosine arabinoside (ara-C) analog was synthesized and characterized by analytical and spectroscopic methods. Especially the data obtained from FT-IR spectroscopy showed that ara-C coordinated with copper(II) ions through –C=O and -Nring groups and formed a complex compound in a tetrahedral structure. The proposed structure of this dimeric copper(II) complex was defined as [Cu2(ara-C)2Cl4]. Also, the ability of both compounds to bind to double helix fish sperm DNA (dsDNA) and the damage to the HeLa cell line was investigated. All theoretical chemical activity analyses (hardness and softness parameters, Fukui functions, net charges) of the ara-C and [Cu2(ara-C)2Cl4] molecules were performed with DFT with mixed basis set including LANL2DZ for Cu atom and 6-311G(d,p) for carbon, oxygen, nitrogen, chlorine and hydrogen atoms with B3LYP functional was … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 4 |