Cord blood metabolomic profiling in high risk newborns born to diabetic, obese, and overweight mothers: preliminary report
Yazarlar (9)
Prof. Dr. Özlem Ünal Uzun Kocaeli Üniversitesi, Türkiye
Duygu Eneş
Başkent Üniversitesi, Türkiye
Başkent Üniversitesi, Türkiye
Müge Çlnar
Kocaeli Üniversitesi, Türkiye
Kocaeli Üniversitesi, Türkiye
Ayla Günlemez Adugit Kocaeli Üniversitesi, Türkiye
Büşra Uçar
Hacettepe Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
Ali Duranoǧlu Kocaeli Üniversitesi, Türkiye
Öğr. Gör. Ufuk BOZKURT OBUZ Sinop Üniversitesi, Türkiye
Mustafa Çelebier Hacettepe Üniversitesi, Türkiye
Prof. Dr. Incilay Lay Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Pediatric Endocrinology and Metabolism (Q3) | ||
| Dergi ISSN | 0334-018X Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 08-04-2025 |
| Cilt / Sayı / Sayfa | 38 / 6 / 577–589 | DOI | 10.1515/jpem-2024-0605 |
| Makale Linki | https://www.degruyterbrill.com/document/doi/10.1515/jpem-2024-0605/html | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
|
||
| Özet |
| Objectives Newborns of diabetic and obese/overweight mothers face long-term metabolic risks. Untargeted cord blood metabolomic analysis using quadrupole time-of-flight liquid chromatography/mass spectrometry (Q-TOF LC/MS) was performed to explore metabolic alterations and pathways in these high-risk infants. Methods Cord blood samples were collected from 46 newborns born to mothers with gestational diabetes (10), obesity (14), overweight (18), type 2 diabetes mellitus (3), type 1 diabetes mellitus (1), and 20 newborns born to healthy mothers. Q-TOF LC/MS was used to investigate the alterations in cord blood metabolomic profiles. Data processing was conducted using MZmine 2.53. Putative metabolites were idendtified using MetaboAnalyst 6.0. Results Distinct metabolite profiles were observed between diabetes and control groups. Significant identical trend in 19 metabolites were determined in … |
| Anahtar Kelimeler |
| high-risk newborn | maternal diabetes | maternal obesity | metabolomics | quadrupole flight time mass spectrometer |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 2 |