New Azo-Azomethine Compounds: Comprehensive Evaluation of In Silico Biological Activities, ADMEt Profiling, and In Vitro Antioxidant Properties
Yazarlar (1)
Doç. Dr. Tolga Acar YEŞİL Sinop Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2025 |
| Cilt / Sayı / Sayfa | 10 / 12 / – | DOI | 10.1002/slct.202405875 |
| Makale Linki | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202405875 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
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| Özet |
| The discovery of novel azo‐azomethine compounds and the exploration of their biological activities are critical for expanding the pool of potential drug candidates. In this study, four new fluorine‐substituted azo‐azomethines (4a–d), containing groups such as ─CF₃ and ─OCF₃, were successfully synthesized in high yields. Their in vitro antioxidant activities were evaluated using the CUPRAC method, and the results indicate that all compounds demonstrated higher TEAC values compared to the standard antioxidant Trolox. Notably, compound 4d exhibited the highest value of 2.22. A comparative analysis indicated that the antioxidant activity was influenced not only by the presence of fluorine‐based substituents but also by the number of hydroxyl (─OH) groups in their structures. The ADMEt properties were also assessed, revealing that the synthesized compounds adhered to Lipinski's rule of five. Additionally … |
| Anahtar Kelimeler |
| ADMEt profiling | Azo compounds | Azomethines | In vitro antioxidant | Molecular docking |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 15 |
| Google Scholar | 21 |