Novel diamide derivatives: Synthesis, characterization, urease inhibition, antioxidant, antibacterial, and molecular docking studies
Yazarlar (1)
Doç. Dr. Şükriye ÇAKMAK Sinop Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2022 |
| Cilt / Sayı / Sayfa | 1261 / 1 / 1–12 | DOI | 10.1016/j.molstruc.2022.132932 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2022.132932 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
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| Özet |
| Novel diamides (I-VI) were synthesized, corroborated by various spectroscopic techniques including IR, 1H NMR, 13C NMR, mass spectrophotometry and elemental analysis. The in vitro screening of the newly synthesized compounds was evaluated for their urease inhibition activity and compound IV was found the most potent derivative with 2.5-fold more enhanced activity (IC50 = 8.17 ± 0.39 mg/mL) than the standard drug thiourea (IC50 = 20.79 ± 0.34 mg/mL). The molecular docking study supported the experimental results and revealed that compound IV has shown a significant dock score and binds within the active site of the target enzyme. Furthermore, these compounds were investigated for their efficacy as antioxidant and antimicrobial agents in vitro. Among all the tested compounds, compound I (IC50 = 45.88±3.99 µg/mL) showed the highest antioxidant activity, whereas compound VI (IC50 = 124.60±2.20 … |
| Anahtar Kelimeler |
| Acylation template | Biological activity | Diamide | Molecular docking | Spectroscopic elucidation | Urease inhibition |
Science Direct
Novel diamide derivatives: Synthesis, characterization, urease inhibition, antioxidant, antibacterial, and molecular docking studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 18 |
| Google Scholar | 24 |