Preparation, structural analysis, bioactivity assessment, enzyme and molecular docking calculations of some furan/ thiophene-2-carboxamide derivatives
Yazarlar (3)
Doç. Dr. Şükriye ÇAKMAK Sinop Üniversitesi, Türkiye
Semiha Yenigün Ondokuz Mayıs Üniversitesi, Türkiye
Prof. Dr. Tevfik Özen Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of the Iranian Chemical Society (Q3) | ||
| Dergi ISSN | 1735-207X Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2023 |
| Cilt / Sayı / Sayfa | 20 / 10 / 2543–2553 | DOI | 10.1007/s13738-023-02852-4 |
| Makale Linki | https://doi.org/10.1007/s13738-023-02852-4 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
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| Özet |
| Some furan/thiophene-2-carboxamide derivatives (1–3) were prepared from acyl chlorides and heterocyclic amine derivatives with good yields, employing synthetic route and their chemical structures were confirmed using different spectroscopic methods including IR, 1H NMR, 13C NMR and elemental analysis. Three different enzyme inhibition effect tests as urease, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibiting activities, were applied to these compounds. The biological evaluation results clearly showed that the compound 1 showed approximately 9.8-fold more activity against urease enzyme than thiourea standard while the compound 3 showed approximately 4.2-fold more activity against BChE enzyme than galantamine standard. The molecular interaction for each of the target compounds with the active sites of the urease, acetylcholinesterase and butyrylcholinesterase enzymes was … |
| Anahtar Kelimeler |
| Amides | Carboxamide | Enzyme inhibitor | Molecular docking | Spectroscopic studies |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 3 |
| Google Scholar | 4 |