Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone
Yazarlar (9)
Hasan Yakan Ondokuz Mayis Üniversitesi, Türkiye
Hiba H.S. Omer Ondokuz Mayis Üniversitesi, Türkiye
Osman Buruk
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Şükriye ÇAKMAK Sinop Üniversitesi, Türkiye
Sarmad Marah
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Aysel VEYİSOĞLU Sinop Üniversitesi, Türkiye
Halit Muğlu Kastamonu University, Türkiye
Prof. Dr. Tevfik Ozen Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Halil Kütük Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2023 |
| Cilt / Sayı / Sayfa | 1277 / 1 / 134799–14 | DOI | 10.1016/j.molstruc.2022.134799 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2022.134799 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
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| Özet |
| New Schiff bases bearing 5-nitroisatin-thiocarbohydrazone (1-9) have been prepared. The chemical structures of these compounds have been clarified by spectroscopic methods (IR, 1H NMR, and 13C NMR), and elemental analysis. Besides, they have been tested for antimicrobial activity. The antimicrobial activities of the novel compounds have been evaluated using a twofold serial dilution method for Minimum Inhibitory Concentration (MIC) against three gram-positive bacteria, three gram-negative bacteria, and two fungal pathogens. The obtained data showed that compound 7 has excellent activity against gram-strain-positive and gram-strain-negative bacteria. Compound 7 showed better activity than amoxicillin, which is one of the standard drugs used against the E. faecalis pathogen, but showed the same activity as tetracycline. Synthesized compounds could be formed the basis for the development of better … |
| Anahtar Kelimeler |
| Antimicrobial activity | Antioxidant activity | Enzyme inhibitor | Molecular docking | Schiff bases | Spectroscopic studies |
Science Direct
Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 25 |
| Scopus | 25 |
| Google Scholar | 29 |