Peripheral levels of BDNF and sirtuin 1 in migren
Yazarlar (5)
Prof. Dr. Ceyla Irkeç Lokman Hekim Üniversitesi, Türkiye
Dr. Öğr. Üyesi Taylan Altiparmak Gazi Üniversitesi, Türkiye
Dilek Yazici Cezayir
Dr. Öğr. Üyesi Rabia TURAL Sinop Üniversitesi, Türkiye
Nilgün Altan
Türkiye
Makale Türü Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) (SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale)
Dergi Adı JOURNAL OF THE NEUROLOGICAL SCIENCES (Q3)
Dergi ISSN 0022-510X Dergi Bilgileri (2017)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili Türkçe Basım Tarihi 10-2017
Cilt / Sayı / Sayfa 381 / 0 / 430–430 DOI 10.1016/j.jns.2017.08.3426
UAK Araştırma Alanları
Tıbbi Biyokimya
Özet
Background: Migraine is a common neurological disorder and its mechanism haven’t been understood. It has been promised that; neurogenic inflammation, cortical spreading depression, central sensitization and vascular involvement causes pain during migraine attacks. Various neuropeptides, cytokines and chemokines have been shown to mediate nociceptive effects. Brain derived neurotrophic factor (BDNF) is a neurotrophin that has been implicated in the modulation of pain signaling. It is expressed in trigeminal ganglion neurons. On the other hand sirtuin 1 (SIRT1) is a member of the hystone deacetylase family proteins and a key regulator of DNA damage, cell survival, metabolism, synaptic plasticity, memory formation, autophagy and neurodegeneration. It modulates BDNF expression and could contribute to pain.Objective: Our objective is to examine the serum levels of this molecules in migraine patients …
Anahtar Kelimeler
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 2
Google Scholar 2
Peripheral levels of BDNF and sirtuin 1 in migren

Paylaş