Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?
Yazarlar (10)
E. Erkılıç Ankara Yildirim Beyazit University, Türkiye
E. Kesimci Ankara Yildirim Beyazit University, Türkiye
F. Alaybeyoğlu
Ankara Yildirim Beyazit University, Türkiye
Ankara Yildirim Beyazit University, Türkiye
I. Kılınç Ankara Yildirim Beyazit University, Türkiye
Dr. Öğr. Üyesi Rabia TURAL Sinop Üniversitesi, Türkiye
A. Yazgan
Ankara Yildirim Beyazit University, Türkiye
Ankara Yildirim Beyazit University, Türkiye
T. Gümüş
Ankara Yildirim Beyazit University, Türkiye
Ankara Yildirim Beyazit University, Türkiye
A. Sepici Dinçel Gazi Üniversitesi, Türkiye
E. G. Dumlu Ankara Yildirim Beyazit University, Türkiye
O. Kanbak
Ankara Yildirim Beyazit University, Türkiye
Ankara Yildirim Beyazit University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Drug Design Development and Therapy (Q2) | ||
| Dergi ISSN | 1177-8881 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Ingilizce | Basım Tarihi | 03-2017 |
| Cilt / Sayı / Sayfa | 11 / 1 / 677–683 | DOI | 10.2147/DDDT.S126701 |
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| BackgroundIschemia–reperfusion (I/R) injury is a common cause of patient morbidity and mortality in the perioperative period. Patients undergoing long-lasting, abdominal, and urogenital surgeries with risk factors such as advanced age, peripheral artery disease, diabetes mellitus, renovascular disease, and congestive heart failure are candidates for acute kidney injury (AKI) due to impaired renal perfusion and decreased functional renal reserve. Pharmacological agents with multiple functions and anti-oxidative and anti-inflammation properties may be promising preventative strategies for AKI. Recently, dexmedetomidine (dex) has been postulated to have renoprotective effects.ObjectivesWe aimed to investigate the protective effects of an intravenous anesthetic remifentanil in renal I/R injury in the rat in comparison with dex.Materials and methodsA total of 30 Sprague Dawley adult rats were randomly assigned … |
| Anahtar Kelimeler |
| Dexmedetomidine | Ischemia–reperfusion | Neutrophil gelatinase-associated lipocalin | Remifentanil |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 18 |
| Scopus | 20 |
| Google Scholar | 18 |