Caffeine Habituation, not CYP1A2 Genotype, Modulates the Acute Effect of Caffeine on Exercise-Induced Hemostatic Responses in Adults with Obesity
Yazarlar (6)
Doç. Dr. Heıdar Sajedı International Science And Technology University, Türkiye
Doç. Dr. Elif Aydın Ardahan Üniversitesi, Türkiye
Prof. Dr. Özlem KESKİN Sinop Üniversitesi, Türkiye
Doç. Dr. Sertaç Erciş Atatürk Üniversitesi, Türkiye
Prof. Dr. Selahattin Akpınar Düzce Üniversitesi, Türkiye
Davar Khodadadi
Islamic Azad University, Central Tehran Branch
Islamic Azad University, Central Tehran Branch
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Medicine and Science in Sports and Exercise (Q1) | ||
| Dergi ISSN | 0195-9131 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Kabul Tarihi | 03-07-2025 | Yayınlanma Tarihi | 10-07-2025 |
| Cilt / Sayı / Sayfa | 57 / 12 / 2656–2666 | DOI | 10.1249/MSS.0000000000003816 |
| Makale Linki | https://doi.org/10.1249/mss.0000000000003816 | ||
| UAK Araştırma Alanları |
Hareket ve Beceri Öğretimi
Fiziksel Uygunluk
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| Özet |
| Purpose This study aimed to investigate how genotype and caffeine habituation influence the acute effects of caffeine ingestion on exercise-induced hemostatic responses in individuals with obesity. Methods Using a randomized, double-blind, placebo-controlled crossover design, 40 physically inactive young men with obesity (age, 22.2 ± 2.3 years; BMI, 34.1 ± 2.7 kg/m2) completed two moderate-to-high-intensity concurrent exercise sessions following ingestion of caffeine (3 mg/kg) or placebo. Blood samples were collected at baseline, after exercise, and after 60 minutes of recovery. Statistical analysis was performed by repeated measures MANOVA. Results Acute exercise increased platelet count and aggregation, fibrinogen, F1 + 2, tPA antigen, D-dimer, and clot lysis time, regardless of genotype or caffeine habituation status (P 0.05) but decreased following recovery (P 0.05). Conclusions Moderate-to-high-intensity concurrent exercise induces a transient prothrombotic state in physically inactive individuals with obesity. Acute caffeine supplementation at a moderate dose modulates the hemostatic responses depending on caffeine habituation status rather than CYP1A2 genotype: it exacerbates the prothrombotic response in naïve consumers but attenuates it in habitual consumers. |
| Anahtar Kelimeler |
| CAFFEINE | COAGULATION | CONCURRENT EXERCISE | FIBRINOLYSIS | OBESITY | PLATELET AGGREGATION |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |