Efficient syntheses crystal structure thermal and biological evaluation of amlodipine 4 chlorobenzoyl 4 chlorobenzene and 2 5 dichlorobenzene sulfonamide derivatives
Yazarlar (5)
Nosheen Kanwal
Lahore College For Women University, Pakistan
Lahore College For Women University, Pakistan
Islam Ullah Khan
Government College University Lahore, Pakistan
Government College University Lahore, Pakistan
Erum Akbar Hussain
Lahore College For Women University, Pakistan
Lahore College For Women University, Pakistan
Sidra Farid
Government College University Lahore, Pakistan
Government College University Lahore, Pakistan
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Comptes Rendus Chimie (Q2) | ||
| Dergi ISSN | 1631-0748 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2016 |
| Cilt / Sayı / Sayfa | 19 / 5 / 594–603 | DOI | 10.1016/j.crci.2016.01.015 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1631074816000400 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| An efficient synthesis of new A-2, A-3, and A-4 analogues from amlodipine (A-1) has been achieved. All synthesized compounds were investigated by elemental analysis, FTIR, EIMS, and 1 H NMR techniques. Crystal structures of A-2 and A-3 were determined by single crystal X-ray diffraction method. Compound A-2 crystallizes in a monoclinic space group C 2/c having unit cell parameters a= 23.8754 (9) Å, b= 8.6725 (3) Å, c= 30.5777 (12) Å, β= 90.673 (2), and V= 6331.0 (4) Å 3, whereas A-3 crystallizes in a triclinic space group P 1 having unit cell parameters a= 8.2968 (3) Å, b= 9.3112 (4) Å, c= 18.1359 (7) Å, α= 100.692 (2), β= 98.316 (3), γ= 102.747 (2), and V= 1317.39 (9) Å 3. These compounds showed that C–H⋯ O and N–H⋯ O hydrogen bonds stabilize the crystal packing. The results of thermal analysis of all products were consistent with the proposed stoichiometry and compounds were found thermally stable up to 200 C. The compounds were tested for direct free radical scavenging effect toward α, α-Diphenyl-1-picryl hydrazide (DPPH•) and 2, 2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)(ABTS•+) radical cation in aqueous phosphate-buffered saline of pH 7.4 and showed significant in vitro antioxidant potential. Antiurease activity was also performed; A-2 and A-4 showed excellent results with dose independency. |
| Anahtar Kelimeler |
| Amlodipine derivatives | Antioxidant potential | Antiurease activity | Crystal structure | Synthesis |
Science Direct
Efficient syntheses crystal structure thermal and biological evaluation of amlodipine 4 chlorobenzoyl 4 chlorobenzene and 2 5 dichlorobenzene sulfonamide derivatives
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 4 |