Synthesis, structural, thermal elucidation and in vitro anticancer activity of novel silver(I) complexes with non-steroidal anti-inflammatory drugs diclofenac and mefenamic acid including picoline derivatives
Yazarlar (4)
Prof. Dr. Ahmet Altay Erzincan Binali Yıldırım Üniversitesi, Türkiye
Prof. Dr. Sema Çağlar Erzincan Binali Yıldırım Üniversitesi, Türkiye
Bülent Çağlar Erzincan Binali Yıldırım Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Polyhedron (Q1)
Dergi ISSN 0277-5387 Dergi Bilgileri (2018)
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce Basım Tarihi 09-2018
Kabul Tarihi Yayınlanma Tarihi 01-09-2018
Cilt / Sayı / Sayfa 151 / 1 / 160–170 DOI 10.1016/j.poly.2018.05.038
Makale Linki https://linkinghub.elsevier.com/retrieve/pii/S0277538718302766
UAK Araştırma Alanları
Yoğun Madde Fiziği
Özet
Six new Ag(I) coordination complexes, namely [Ag4(μ-dicl)4(2-pic)3] 1, [Ag2(μ-mef)2(2-pic)2] 2, [Ag2(μ-dicl)2(3-pic)2] 3, [Ag2(μ-mef)2(3-pic)2] 4, [Ag2(μ-dicl)2(4-pic)2] 5 and [Ag2(μ-mef)2(4-pic)2] 6, were synthesized and characterized by elemental analysis, FT-IR and thermal analysis techniques. The crystal structures of 1, 3, 4 and 5 were determined by X-ray diffraction analysis, whereas 2 and 6 were obtained as microcrystalline powders. X-ray diffraction analysis demonstrated that 1 occurs as a tetranuclear complex, while 3, 4 and 5 have binuclear structures. A short Ag⋯Ag distances of 2.8446 and 2.8823 Å for 1, 2.8409 Å for 3, 2.8942 Å for 4 and 2.8423 Å for 5 were found in the complexes, indicating that argentophilic interactions exist between the silver ions. In 1, the dicl ligands act as μ3-O,O′,O′ bridging ligands between three Ag(I) ions. In 3, 4 and 5, the dicl and mef ligands behave as bridging ligands …
Anahtar Kelimeler
Cell culture | Cytotoxicity | Diclofenac | Mefenamic acid | Silver(I) complexes