Green and Facile Reaction of Gabapentin with Sulfonyl Chlorides to Synthesize Lactams and Sulfonamides Derivatives in Aqueous Medium
Yazarlar (10)
Erum Akbar Hussain
Lahore College For Women University, Pakistan
Lahore College For Women University, Pakistan
Nosheen Kanwal
Lahore College For Women University, Pakistan
Lahore College For Women University, Pakistan
Islam Ullah Khan
Government College University Lahore, Pakistan
Government College University Lahore, Pakistan
Sadaf Mutahir
Government College University Lahore, Pakistan
Government College University Lahore, Pakistan
Muhammad Asim Khan
Nanjing University Of Science And Technology, Çin
Nanjing University Of Science And Technology, Çin
Maqsood Ahmed
The Islamia University Of Bahawalpur, Pakistan
The Islamia University Of Bahawalpur, Pakistan
Arshad Mahmood
Nanjing University Of Science And Technology, Çin
Nanjing University Of Science And Technology, Çin
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Mehmet Akkurt Erciyes Üniversitesi, Türkiye
Muhammad Yar
Comsats Institute Of Information Technology Lahore, Pakistan
Comsats Institute Of Information Technology Lahore, Pakistan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Letters in Organic Chemistry (Q4) | ||
| Dergi ISSN | 1570-1786 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 07-02-2018 |
| Cilt / Sayı / Sayfa | 15 / 3 / 163–170 | DOI | 10.2174/1570178614666170907143340 |
| Makale Linki | http://www.eurekaselect.com/155412/article | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In the current research, a facile and green one pot synthesis of new gabapentin-lactams (G2-G8) has been achieved by reacting gabapentin (G1) with a variety of sulfonyl chlorides. The new lactamization protocol is furnished under the green solvent i.e., water and reaction was completed in a short period of time by just stirring at room temperature. Whereas in some cases, annulation could not happen and furnished un-cyclized sulfonamide products (G9-G12). The structures of the targeted compounds were established by elemental analysis, FT-IR, 1H-NMR and mass spectrometry. The crystals of some new lactams (G2, G3, G4, and G8) were also evaluated by single crystal X-ray diffraction. |
| Anahtar Kelimeler |
| Crystal structure | Facile reaction | Gabapentin | Green synthesis | Lactams | Sulfonamides |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 4 |
| Google Scholar | 6 |