Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity
Yazarlar (5)
Prof. Dr. Esra Dilek Erzincan Binali Yıldırım Üniversitesi, Türkiye
Prof. Dr. Sema Çağlar Erzincan Binali Yıldırım Üniversitesi, Türkiye
Öğr. Gör. Kübra Erdoğan Erzincan Binali Yıldırım Üniversitesi, Türkiye
Bülent Çağlar Erzincan Binali Yıldırım Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Biochemical and Molecular Toxicology (Q2) | ||
| Dergi ISSN | 1095-6670 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 07-03-2018 |
| Cilt / Sayı / Sayfa | 32 / 4 / 22043–0 | DOI | 10.1002/jbt.22043 |
| Makale Linki | http://doi.wiley.com/10.1002/jbt.22043 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In this study, the effects of four novel mononuclear palladium(II) and platinum(II) complexes on the activity of human serum paraoxanase1 were examined. First, four novel mononuclear palladium(II) and platinum(II) complexes were synthesized with a nitrogen donor ligand 1‐(2‐aminoethyl)pyrrolidine and nonsteroidal anti‐inflammatory drugs diclofenac, mefenamic acid. These complexes were characterized by spectroscopic, thermal, and elemental analyses. The crystal structures of complex [Pd(2‐amepyr)2](dicl)2 1 and [Pd(2‐amepyr)2](mef)2 3 were determined by X‐ray crystallography. Then, paraoxonase1 enzyme was purified from human serum. The effects of these complexes on enzyme were evaluated in vitro. The complexes consist of the cationic unit and the counterions. The diclofenac and mefenamic acid acted as a counterion in the complexes. It was observed that all the complexes were stable up to … |
| Anahtar Kelimeler |
| crystal structure | enzyme inhibition | palladium(II) and platinum(II) complexes | paraoxonase1 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 7 |
| Google Scholar | 15 |