Synthesis, crystal structure, spectroscopy, thermal properties and carbonic anhydrase activities of new metal(II) complexes with mefenamic acid and picoline derivatives
Yazarlar (6)
Prof. Dr. Esra Dilek Erzincan Üniversitesi, Türkiye
Prof. Dr. Sema Çağlar Erzincan Üniversitesi, Türkiye
Nesrin Doğançay
Erzincan Binali Yıldırım Üniversitesi, Türkiye
Bülent Çağlar Erzincan Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Ahmet Tabak Sinop Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Coordination Chemistry (Q2)
Dergi ISSN 0095-8972 Dergi Bilgileri (2017)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 07-2017
Kabul Tarihi 14-07-2017 Yayınlanma Tarihi 18-08-2017
Cilt / Sayı / Sayfa 70 / 16 / 2833–2852 DOI 10.1080/00958972.2017.1366996
Makale Linki https://www.tandfonline.com/doi/full/10.1080/00958972.2017.1366996
UAK Araştırma Alanları
Yoğun Madde Fiziği
Özet
The mononuclear six metal(II) complexes ([Co(mef)2(3-pic)2(CH3OH)2] (1), [Ni(mef)2(3-pic)2(CH3OH)2] (2), [Cu(mef)2(3-pic)2] (3), [Co(mef)2(4-pic)2] (4), [Ni(mef)2(4-pic)2] (5), and [Cu(mef)2(4-pic)2] (6) with mefenamic acid and picoline ligands were synthesized, characterized, and their carbonic anhydrase inhibitory activities were evaluated. The six complexes were characterized by elemental analysis, FT-IR spectroscopy, and thermal analyses. The crystal structures of 1, 3, and 6 were determined by X-ray crystallography. The complexes have octahedral geometry. In 1, the mefenamato ligand behaved as monodentate whereas in 3 and 6, the mefenamato ligand acted as a bidentate ligand. Complexes 3 and 6 consist of the mefenamate and 4-picoline ligands. In 1, unlike the other complexes, methanol acted as a ligand and was involved in the coordination. Carbonic anhydrase I and II isoenzymes were purified …
Anahtar Kelimeler
carbonic anhydrases | Mefenamic acid | metal complex | picoline