Efficient Syntheses, Crystal Structure and Thermal Properties of Gabapentin 4-Acetamido, 2-Mesitylene and 2,4-Dinitro Sulfonamides Derivatives
Yazarlar (6)
Nosheen Kanwal
Lahore College For Women University, Pakistan
Islam Ullah Khan
Government College University Lahore, Pakistan
Shahzad Sharif
Government College University Lahore, Pakistan
Erum Akbar Hussain
Lahore College For Women University, Pakistan
Arshad Mehmood
Government College University Lahore, Pakistan
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Chemical Crystallography (Q3)
Dergi ISSN 1074-1542 Dergi Bilgileri (2019)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 09-2019
Kabul Tarihi 22-12-2018 Yayınlanma Tarihi 02-01-2019
Cilt / Sayı / Sayfa 49 / 3 / 162–168 DOI 10.1007/s10870-018-00765-2
Makale Linki http://link.springer.com/10.1007/s10870-018-00765-2
UAK Araştırma Alanları
Yoğun Madde Fiziği
Özet
Efficient syntheses of four derivatives G2–G5 of Gabapentin (G1) have been achieved. The structures of targeted compounds were investigated by elemental analysis, FT-IR, and 1H-NMR spectroscopic method. Crystal structures of G2 and G4 determined by single crystal X-ray diffraction method are also described. In G2 the molecules are stacked over each other in the form of layers and adjacent layers run parallel to each other. Intermolecular hydrogen bonding and van der Waals interactions are responsible for building the molecular assembly and packing of molecules in the unit. In G4, the molecules are arranged in parallel sheets formed by inter-molecular hydrogen bonds. The proposed synthetic route has high impact due to its simple reaction conditions of room temperature, water as a green solvent and short time to accomplish the reaction.Graphical AbstractSynthesis of Gabapentin sulfonamide derivatives …
Anahtar Kelimeler
Crystal structure | Gabapentin | Sulfonamides | Synthesis | Thermal analysis