Structural analysis and biological functionalities of iron(III)– and manganese(III)–thiosemicarbazone complexes: in vitro anti-proliferative activity on human cancer cells, DNA binding and cleavage studies
Yazarlar (6)
Arş. Gör. Büşra Kaya Marmara Üniversitesi, Türkiye
Arş. Gör. Zehra Kübra Yılmaz Gazi Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Belma Aslim Gazi Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ümmügülsüm Tükenmez Mardin Artuklu Üniversitesi, Türkiye
Bahri Ülküseven
İstanbul Üniversitesi-Cerrahpaşa, Türkiye
İstanbul Üniversitesi-Cerrahpaşa, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Journal of Biological Inorganic Chemistry (Q1) | ||
| Dergi ISSN | 0949-8257 Dergi Bilgileri (2019) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2019 |
| Kabul Tarihi | 13-03-2019 | Yayınlanma Tarihi | 20-03-2019 |
| Cilt / Sayı / Sayfa | 24 / 3 / 365–376 | DOI | 10.1007/s00775-019-01653-6 |
| Makale Linki | http://link.springer.com/10.1007/s00775-019-01653-6 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
|
||
| Özet |
| One iron(III) and two manganese(III) complexes based on thiosemicarbazone were synthesized and characterized using analytical and spectroscopic data. The crystallographic analysis showed the square pyramid structures of the complexes. Electronic spectra analysis was performed to determine the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were examined by gel electrophoresis (pBR322 DNA). The cytotoxicity of the complexes was determined against human cervical carcinoma (HeLa) and human colorectal adenocarcinoma (HT-29) cell lines by MTT assay. The results indicated that complex Fe1 is bound to CT-DNA via the intercalation mode, while complexes Mn1 and Mn2 are bound to CT-DNA via groove binding and/or electrostatic interactions rather than the intercalation mode. In addition, they showed good binding activity … |
| Anahtar Kelimeler |
| Anti-proliferation | DNA binding | DNA cleavage | Iron | Manganese | Thiosemicarbazone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 30 |
| Scopus | 32 |
| Google Scholar | 32 |