Synthesis and cytotoxic activities of organometallic Ru(II) diamine complexes
Yazarlar (8)
Serdar Batıkan Kavukcu Ege Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Hafize Seda Vatansever Manisa Celâl Bayar Üniversitesi, Türkiye
Prof. Dr. Feyzan Ozdal Kurt Manisa Celâl Bayar Üniversitesi, Türkiye
Prof. Dr. Mehmet Korkmaz Manisa Celâl Bayar Üniversitesi, Türkiye
Remziye Kendirci
Manisa Celâl Bayar Üniversitesi, Türkiye
Manisa Celâl Bayar Üniversitesi, Türkiye
Prof. Dr. Levent Pelit Ege Üniversitesi, Türkiye
Prof. Dr. Hayati Türkmen Ege Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Bioorganic Chemistry (Q1) | ||
| Dergi ISSN | 0045-2068 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-06-2020 |
| Cilt / Sayı / Sayfa | 99 / 1 / 103793–0 | DOI | 10.1016/j.bioorg.2020.103793 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0045206819312775 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| A series of mono and bimetallic ruthenium(II) arene complexes bearing diamine (Ru1-6) were prepared and fully characterized by 1H, 13C, 19F, and 31P NMR spectroscopy and elemental analysis. The crystal structure of the bimetallic complex (Ru5) was determined by X-ray crystallography. Monometallic analogues (Ru1-3) were synthesized to investigate the contributions of ruthenium and the other organic groups (aren, ethylenediamine, butyl) to the activity. The electrochemical behaviors of mono and bimetallic complexes were obtained from the relationship between cyclic voltammetry (CV) and the biological activities of the compounds. The cytotoxic activities of the complexes (Ru1-6) were tested against wide-scale cancer cell lines, namely HeLa, MDA-MB-231, DU-145, LNCaP, Hep-G2, Saos-2, PC-3, and MCF-7, and normal cell lines 3T3-L1 and Vero. Diamine Ru(II) arene complexes have unique biological … |
| Anahtar Kelimeler |
| Bimetallic complex | Cancer | Cytotoxicity | Ruthenium(II) arene complex |
Science Direct
Synthesis and cytotoxic activities of organometallic Ru(II) diamine complexes
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 15 |
| Google Scholar | 18 |