Regio- and stereospecific synthesis of rac -carbasugar-based cyclohexane pentols Investigations of their α - and β -glucosidase inhibitions
Yazarlar (5)
Emel Karakılıç
Sakarya Üniversitesi, Türkiye
Sakarya Üniversitesi, Türkiye
Sümeyye Durmuş
Sakarya Üniversitesi, Türkiye
Sakarya Üniversitesi, Türkiye
Sedat Sevmezler
Sakarya Üniversitesi, Türkiye
Sakarya Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Arif Baran Sakarya Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Bioorganic and Medicinal Chemistry (Q1) | ||
| Dergi ISSN | 0968-0896 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-08-2018 |
| Cilt / Sayı / Sayfa | 26 / 14 / 4276–4287 | DOI | 10.1016/j.bmc.2018.07.021 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0968089618310265 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In the present study, (3aR,7aS)-1,3,3a,4,7,7a-hexahydroisobenzofuran was submitted to photooxygenation and two isomeric hydroperoxides were successfully obtained. Without any further purification, reduction of the hydroperoxides with titanium tetraisopropoxide catalyzed by dimethyl sulfide gave two alcohol isomers in high yields. After acetylation of alcohol with Ac2O in pyridine, epoxidation reaction of formed monoacetates with m-CPBA, then chromatographed and followed by hydrolysis of the acetate groups with NH3 in CH3OH resulted in the formation of epoxy alcohol isomers respectively. These epoxy alcohol isomers were subjected to trans-dihydroxylation reaction with acid (H2SO4) in the presence of water to afford triols. Acetylation of the free hydroxyl groups produced benzofuran triacetates in high yields. Ring-opening reaction of furan triacetates with sulfamic acid catalyzed in the presence of acetic … |
| Anahtar Kelimeler |
| Biological activity | Carbasugar | Cyclitol | “ene” Reaction |
Science Direct
Regio- and stereospecific synthesis of rac -carbasugar-based cyclohexane pentols Investigations of their α - and β -glucosidase inhibitions
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 6 |
| Google Scholar | 5 |