S-alkylated thiosemicarbazone derivatives: Synthesis, crystal structure determination, antimicrobial activity evaluation and molecular docking studies
Yazarlar (7)
Prof. Dr. Miyase Gözde Gündüz Hacettepe Üniversitesi, Türkiye
Arş. Gör. Büşra Kaya Istanbul University-Cerrahpasa, Türkiye
Ceren Özkul
Hacettepe Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Estharla Madhu Rekha
Birla Institute Of Technology And Science, Pilani, Hindistan
Birla Institute Of Technology And Science, Pilani, Hindistan
Dharmarajan Sriram
Birla Institute Of Technology And Science, Pilani, Hindistan
Birla Institute Of Technology And Science, Pilani, Hindistan
Bahri Ülküseven
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q3) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2021 |
| Cilt / Sayı / Sayfa | 1242 / 1 / 130674–0 | DOI | 10.1016/j.molstruc.2021.130674 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2021.130674 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Increasing antimicrobial resistance is one of the most serious threats to human health worldwide. Therefore, there is an urgent need for the discovery of novel antimicrobial agents. Herein, we presented the synthesis of ten thiosemicarbazone derivatives (T1-T10) obtained by the reaction of S-alkylthiosemicarbazide with various dicarbonyl derivatives. The compounds were characterized by IR, 1H NMR, ESI-MS and X-ray crystallography. Reaction with the dicarbonyl compound bearing the 4-fluorobenzoyl group unexpectedly gave a pyrazole derivative (T8) containing the entire S-methylthiosemicarbazone backbone. We extensively screened these derivatives for their antimicrobial activities against Mycobacterium tuberculosis and various bacterial and Candida strains. Additionally, the biofilm inhibition capacity of T8 was evaluated on Staphylococcus epidermidis and Pseudomonas aeruginosa biofilm positive … |
| Anahtar Kelimeler |
| Antibacterial | Antifungal | Quorum sensing | Thiosemicarbazone | Tuberculosis | X-ray analysis |
Science Direct
S-alkylated thiosemicarbazone derivatives: Synthesis, crystal structure determination, antimicrobial activity evaluation and molecular docking studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 16 |
| Google Scholar | 21 |