Oxovanadium(IV) complexes with tetradentate thiosemicarbazones. Synthesis, characterization, anticancer enzyme inhibition and in vitro cytotoxicity on breast cancer cells
Yazarlar (7)
Dr. Öğr. Üyesi Onur Ertik Istanbul University-Cerrahpasa, Türkiye
Doç. Dr. Ferdane Danısman Kalındemirtas İstanbul Tıp Fakültesi, Türkiye
Arş. Gör. Buşra Kaya Istanbul University-Cerrahpasa, Türkiye
Prof. Dr. Refiye Yanardağ Istanbul University-Cerrahpasa, Türkiye
Serap Erdem Kuruca
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Bahri Ülküseven
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Polyhedron (Q1) | ||
| Dergi ISSN | 0277-5387 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-07-2021 |
| Cilt / Sayı / Sayfa | 202 / 1 / 115192–0 | DOI | 10.1016/j.poly.2021.115192 |
| Makale Linki | http://dx.doi.org/10.1016/j.poly.2021.115192 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Five oxovanadium(IV) complexes were synthesized using acetyl- and benzoylacetone-S-alkyl-thiosemicarbazones (alkyl=methyl, ethyl, propyl or butyl) and salicylaldehyde. Structural characterization was performed by element analysis, infrared, mass and electronic spectra, and also single crystal X-ray crystallography for one sample. The purity of all the complexes was verified with Miller indices (hkl) observed and calculated angles, 2θ values and crystal sizes obtained from powder XRD diffraction. The in vitro cytotoxic activity was determined for the MCF-7, MDA-MB-231 and 3T3 cell lines with an MTT assay for 72 h. The complexes showed cytotoxicity against MCF-7, MDA-MB-231 and 3T3 cells at concentrations of 73–148, 75–224 and 112–176 μM, respectively. All the complexes had better cytotoxicity than the positive control, fluorouracil (5-FU). The complex containing the S-propyl group was the most effective … |
| Anahtar Kelimeler |
| Breast cancer | Elastase inhibition | Neuraminidase inhibition | Thiosemicarbazone | Xanthine oxidase inhibition |
Science Direct
Oxovanadium(IV) complexes with tetradentate thiosemicarbazones. Synthesis, characterization, anticancer enzyme inhibition and in vitro cytotoxicity on breast cancer cells
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 24 |
| Scopus | 24 |
| Google Scholar | 30 |