Efficient synthesis and molecular docking studies of new pyrimidine-chromeno hybrid derivatives as potential antiproliferative agents
Yazarlar (5)
Doç. Dr. Sevtap Çağlar Yavuz Erciyes Üniversitesi, Türkiye
Prof. Dr. Senem Akkoç Süleyman Demirel Üniversitesi, Türkiye
Prof. Dr. Burak Tüzün Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Emin Sarıpınar Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Synthetic Communications (Q2) | ||
| Dergi ISSN | 0039-7911 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 26-05-2021 |
| Cilt / Sayı / Sayfa | 51 / 14 / 2135–2159 | DOI | 10.1080/00397911.2021.1922920 |
| Makale Linki | http://dx.doi.org/10.1080/00397911.2021.1922920 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Various novel heterocyclic compounds containing pyrimidine nuclei 5H-chromeno[4,3-d]pyrimidine (4a–c, e–h, l–r, t) and pyrimidine-5-yl-(2-hydroxyphenyl)methanone (5a, c, d, f–k, m–o, r, s, u) were synthesized from the reaction of guanylhydrazones (2a–u) and 3-formylchromone (3). These compounds were tested against human liver hepatocellular carcinoma cell line (HepG2) and human breast adenocarcinoma cell line (MDA-MB-231) using the MTT assay method. Furthermore, molecular docking calculations were performed to compare the biological activities of various novel heterocyclic compounds against cancer proteins. In these calculations, the protein used are crystal structure of the BRCT repeat region from the breast cancer associated protein, 1JNX, crystal structure of VEGFR kinase (liver cancer) protein, 3WZE, and crystal structure of an allosteric Eya2 phosphates inhibitor (lung cancer) protein, 5ZMA … |
| Anahtar Kelimeler |
| Antiproliferative activity | HepG2 | MDA-MB-231 | molecular docking | pyrimidine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 20 |
| Scopus | 21 |
| Google Scholar | 34 |