Iron(III) complexes based on tetradentate thiosemicarbazones: Synthesis, characterization, radical scavenging activity and in vitro cytotoxicity on K562, P3HR1 and JURKAT cells
Yazarlar (7)
Ferdane Danışman Kalındemirtaş İstanbul Tıp Fakültesi, Türkiye
Arş. Gör. Buşra Kaya Istanbul University-Cerrahpasa, Türkiye
Prof. Dr. Mustafa Bener Istanbul Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Serap Erdem Kuruca
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
Prof. Dr. Tülay Bal Demirci Istanbul University-Cerrahpasa, Türkiye
Bahri Ülküseven
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Applied Organometallic Chemistry (Q1) | ||
| Dergi ISSN | 0268-2605 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Kabul Tarihi | 27-12-2020 | Yayınlanma Tarihi | 05-01-2021 |
| Cilt / Sayı / Sayfa | 35 / 4 / 1–11 | DOI | 10.1002/aoc.6157 |
| Makale Linki | http://dx.doi.org/10.1002/aoc.6157 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
|
||
| Özet |
| Nine iron(III) complexes, [Fe(L)Cl], were synthesized starting from S‐alkyl‐thiosemicarbazones and some substituted aldehydes. The L ligands formed by template condensation are N2O2‐chelating structures and named N1‐acetylacetone‐N4‐R‐salicylidene‐S‐alkyl‐thiosemicarbazidato (L2−) where alkyl = methyl, propyl, or allyl and R = 3‐methoxy, 4‐methoxy, or 3,5‐dichloro. The complexes were characterized using elemental analysis, IR, and ESI‐MS. X‐ray diffraction analysis of complex Fe8 (as a representative sample) indicated a square pyramid environment of the iron ion. The cytotoxicity performances of the complexes were determined using chronic myelogenous leukemia (K562), Burkitt's lymphoma (P3HR1), and T‐cell leukemia (JURKAT) cell lines. For comparison, the noncancerous cell lines, human umbilical vein endothelial (HUVEC) and diploid fibroblast (3T3), and imatinib as positive control were … |
| Anahtar Kelimeler |
| antioxidant | cytotoxicity | iron(III) | radical scavenging | thiosemicarbazone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 12 |
| Google Scholar | 14 |