Linking azoles to isoniazid via hydrazone bridge: Synthesis, crystal structure determination, antitubercular evaluation and computational studies
Yazarlar (7)
Arş. Gör. Ebru Koçak Aslan Hacettepe Üniversitesi, Türkiye
Vagolu Siva Krishna
Universitetet İ Oslo, Norveç
Universitetet İ Oslo, Norveç
Sanja J. Armakovic
University Of Novi Sad, Sırbistan
University Of Novi Sad, Sırbistan
Stevan Armakovic
University Of Novi Sad, Sırbistan
University Of Novi Sad, Sırbistan
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Tone Tønjum Universitetet İ Oslo, Norveç
Prof. Dr. Miyase Gözde Gündüz Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Liquids (Q1) | ||
| Dergi ISSN | 0167-7322 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 05-2022 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-05-2022 |
| Cilt / Sayı / Sayfa | 354 / 1 / 118873–0 | DOI | 10.1016/j.molliq.2022.118873 |
| Makale Linki | http://dx.doi.org/10.1016/j.molliq.2022.118873 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| The current emergence of drug-resistant and multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains has complicated and hampered attempts to eliminate or considerably reduce the global prevalence of the often life-threatening disease tuberculosis (TB). Hence, the development of novel antitubercular agents is crucial to combat this challenge. Here, we applied the molecular hybridization approach to link isoniazid (INH), the frontline antitubercular drug, to various azole rings (pyrazole, imidazole, and triazole) through hydrazone functionality. The designed compounds were synthesized and characterized by using spectral techniques including IR, 1H NMR, 13C NMR and HRMS. Additionally, single crystal X-ray analysis was employed to resolve the proposed chemical structure of INH-T. All compounds were then extensively screened for their antitubercular activities against Mtb H37Rv, drug-resistant … |
| Anahtar Kelimeler |
| DFT | Interactions with water | Molecular dynamics | Molecular hybridization | Tuberculosis | X-ray analysis |
Science Direct
Linking azoles to isoniazid via hydrazone bridge: Synthesis, crystal structure determination, antitubercular evaluation and computational studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 23 |
| Scopus | 23 |
| Google Scholar | 24 |