New oxovanadium(IV) complexes overcame drug resistance and increased in vitro cytotoxicity by an apoptotic pathway in breast cancer cells
Yazarlar (6)
Doç. Dr. Ferdane Danışman Kalındemirtaş Erzincan Binali Yıldırım Üniversitesi, Türkiye
Arş. Gör. Buşra Kaya Istanbul University-Cerrahpasa, Türkiye
Esra Sert
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Serap Erdem Kuruca
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
Bahri Ülküseven
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemico Biological Interactions (Q1) | ||
| Dergi ISSN | 0009-2797 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 08-2022 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-08-2022 |
| Cilt / Sayı / Sayfa | 363 / 1 / 109997–0 | DOI | 10.1016/j.cbi.2022.109997 |
| Makale Linki | http://dx.doi.org/10.1016/j.cbi.2022.109997 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In order to examine the anticancer potential of oxovanadium(IV) complexes with thiosemicarbazone, two new complexes were prepared starting from 2-thenoyltrifluoroacetone-S-methylthiosemicarbazone. The complexes with tetradentate thiosemicarbazone ligand were characterized by elemental analysis, IR, ESI MS, and single-crystal X-ray diffraction analysis. Cytotoxicity on breast cancer cells, MDA-MB-231 and MCF-7, was determined by MTT assay. Cisplatin was positive control and the results were compared with those of the normal cells, HUVEC and 3T3. The complexes exhibited greater activity on cancer cells than cisplatin, but they were cytotoxic at several times higher concentrations in the healthy cells. In our study, the presence of thiophene and fluoro groups in the oxovanadium(IV) complexes with thiosemicarbazone increased greatly the cytotoxic activity of the complexes on breast cancer cells … |
| Anahtar Kelimeler |
| Apoptosis | Breast cancer | Cytotoxicity | Multidrug resistance | Thiosemicarbazone | Vanadium complexes |
Science Direct
New oxovanadium(IV) complexes overcame drug resistance and increased in vitro cytotoxicity by an apoptotic pathway in breast cancer cells
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 10 |
| Google Scholar | 12 |