Novel Thioether‐Bridged 2,6‐Disubstituted and 2,5,6‐Trisubstituted Imidazothiadiazole Analogues: Synthesis, Antiproliferative Activity, ADME, and Molecular Docking Studies
Yazarlar (6)
Öğr. Gör. Ibrahim Ozcan Karabük Üniversitesi, Türkiye
Prof. Dr. Senem Akkoç Süleyman Demirel Üniversitesi, Türkiye
Doç. Dr. Hakan Alıcı Zonguldak Bulent Ecevit University, Türkiye
Dr. Öğr. Üyesi Seval Çapanlar Zonguldak Bulent Ecevit University, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Hakan Tahtacı Karabük Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistry and Biodiversity (Q2) | ||
| Dergi ISSN | 1612-1872 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2022 |
| Kabul Tarihi | 29-11-2022 | Yayınlanma Tarihi | 13-12-2022 |
| Cilt / Sayı / Sayfa | 20 / 1 / – | DOI | 10.1002/cbdv.202200884 |
| Makale Linki | http://dx.doi.org/10.1002/cbdv.202200884 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In this study, starting from 2‐amino‐1,3,4‐thiadiazole derivatives (3–5), a new series of 2,6‐disubstituted (compounds 7–15) and 2,5,6‐trisubstituted (compounds 16–33) imidazo[2,1‐b][1,3,4]‐thiadiazole derivatives were synthesized using cyclization and Mannich reaction mechanisms, respectively. All synthesized compounds were characterized by 1H‐NMR, 13C‐NMR, FT‐IR, elemental analysis, and mass spectroscopy techniques. Also, X‐ray diffraction analysis were used for compounds 4, 7, 11, 17, and 19. The cytotoxic effects of the new compounds on the viability of colon cancer cells (DLD‐1), lung cancer cells (A549), and liver cancer cells (HepG2) were investigated using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) method in vitro. Compound 15 was found to be the most potent anticancer drug candidate in this series with an IC50 value of 3.63 μM against HepG2 for 48 h … |
| Anahtar Kelimeler |
| ADME | antiproliferative activity | bioorganic chemistry | cytotoxicity | heterocycles |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 13 |
| Google Scholar | 14 |