Synthesis, biological and theoretical properties of crystal zinc complex with thiosemicarbazone of glyoxylic acid
Yazarlar (9)
Mansura Huseynova
Azerbaijan National Academy Of Sciences, Azerbaycan
Azerbaijan National Academy Of Sciences, Azerbaycan
Vaqif Farzaliyev
Azerbaijan National Academy Of Sciences, Azerbaycan
Azerbaijan National Academy Of Sciences, Azerbaycan
Ajdar Medjidov Azerbaijan National Academy Of Sciences, Azerbaycan
Mahizar Aliyeva
Azerbaijan National Academy Of Sciences, Azerbaycan
Azerbaijan National Academy Of Sciences, Azerbaycan
Dr. Öğr. Üyesi Mücahit Özdemir Marmara Üniversitesi, Türkiye
Doç. Dr. Parham Taslımı Bartin Üniversitesi, Türkiye
Prof. Dr. Yunus Zorlu Gebze Teknik Üniversitesi, Türkiye
Prof. Dr. Bahattin Yalçın Marmara Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2022 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2022 |
| Cilt / Sayı / Sayfa | 1248 / 1 / 131470–0 | DOI | 10.1016/j.molstruc.2021.131470 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2021.131470 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
|
||
| Özet |
| A new zinc complex with thiosemicarbazone of glyoxylic acid (1) was synthesized with zinc acetate dihydrate and thiosemicarbazone of glyoxylic acid and crystallized in water. The absolute crystal structure of the complex was defined using the single-crystal X-ray diffraction technique. It was seen in X-ray measurements that the complex crystallized in the triclinic system with the P-1 space group. The structure of 1 represents distorted octahedral geometry around the central zinc metal. Zn(II) complex with thiosemicarbazone of glyoxylic acid was an inhibitor of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I and II isoforms (hCA I and II) receptors and the inhibitor constant (Ki) values of the synthesized complex were 38.94 ± 8.2 μM for hCA I, 48.62 ± 11.3 μM for hCA II, 65.16 ± 11.4 μM for BChE and 82.04 ± 16.0 μM for AChE, respectively. The molecular docking method was … |
| Anahtar Kelimeler |
| Crystal structure | Enzyme inhibition | Synthesis | Theoretical calculations | Thiosemicarbazones |
Science Direct
Synthesis, biological and theoretical properties of crystal zinc complex with thiosemicarbazone of glyoxylic acid
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 17 |
| Scopus | 19 |
| Google Scholar | 25 |