Design, Synthesis, Cytotoxic Activity, and In Silico Studies of New Schiff Bases Including Pyrimidine Core
Yazarlar (6)
Arş. Gör. Halis Karataş Erciyes Üniversitesi, Türkiye
Meltem Aydın Erciyes Üniversitesi, Türkiye
Doç. Dr. Burçin Türkmenoğlu Erzincan Binali Yıldırım Üniversitesi, Türkiye
Prof. Dr. Senem Akkoç Süleyman Demirel Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Zülbiye Kökbudak Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 02-2023 |
| Cilt / Sayı / Sayfa | 8 / 6 / – | DOI | 10.1002/slct.202204221 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202204221 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In here, two new Schiff base molecules (3 and 4) were synthesized from the condensation reaction of 1‐amino‐5‐benzoyl‐4‐phenylpyrimidine‐2(1H)‐one (1) and 1‐amino‐5‐(4‐methylbenzoyl)‐4‐p‐tolylpyrimidin‐2(1H)‐one (2) with 4‐bromobenzaldehyde. These molecules were completely characterized by IR, NMR, and HR‐MS. Moreover, molecule 4 was determined by single crystal x‐ray diffraction (SC‐XRD) patterns. The crystallographic analysis revealed that molecule 4 crystallizes in the monoclinic system, space group P21/c. The molecules were screened in colon, lung and liver cell lines. The results showed that molecule 4 had cytotoxic activity in all screened cancer cell lines. Molecular docking studies of molecules 3 and 4, which were synthesized experimentally and whose cytotoxic activities were examined, were carried out with in silico approaches. Binding parameter values and active binding … |
| Anahtar Kelimeler |
| ADME prediction | Cytotoxic activity | Molecular docking | Pyrimidine | Schiff Bases |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 12 |
| Google Scholar | 14 |