Linking quinoline ring to 5-nitrofuran moiety via sulfonyl hydrazone bridge: Synthesis, structural characterization, DFT studies, and evaluation of antibacterial and antifungal activity
Yazarlar (8)
Prof. Dr. Şengül Dilem Doğan Erciyes Üniversitesi, Türkiye
Esma Özcan
Erciyes Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Prof. Dr. Yasin Çetinkaya Atatürk Üniversitesi, Türkiye
Doç. Dr. Muhammed İhsan Han Erciyes Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Sanja Skaro Bogojevic
University Of Belgrade, Sırbistan
University Of Belgrade, Sırbistan
Jasmina Nikodinovic-Runic
University Of Belgrade, Sırbistan
University Of Belgrade, Sırbistan
Prof. Dr. Miyase Gözde Gündüz Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2023 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-11-2023 |
| Cilt / Sayı / Sayfa | 1292 / 1 / 136155–0 | DOI | 10.1016/j.molstruc.2023.136155 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2023.136155 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In the present work, we report the synthesis, structural characterization, and computational studies of (E)-N'-((5-nitrofuran-2-yl)methylene)quinoline-8-sulfonohydrazide (QNF) as a potential antimicrobial drug candidate. To design the target molecule, we utilized a molecular hybridization technique that connects two antimicrobial pharmacophores (quinoline and 5-nitrofuran rings) with a sulfonyl hydrazone moiety. QNF was synthesized by the condensation of quinoline-8-sulfonohydrazide with 5-nitrofuran-2-carbaldehyde, and characterized by various spectral techniques including single-crystal X-ray crystallography. QNF was extensively evaluated for its antibacterial and antifungal activity. The inhibition capacity of QNF on Candida albicans filamentation and biofilm formation was further investigated. Biofilm inhibition of QNF against C. albicans was supported by molecular docking studies in the binding site of … |
| Anahtar Kelimeler |
| Antimicrobial | Density functional theory | Hydrogen bond | Intramolecular interactions | Molecular docking | X-ray diffraction |
Science Direct
Linking quinoline ring to 5-nitrofuran moiety via sulfonyl hydrazone bridge: Synthesis, structural characterization, DFT studies, and evaluation of antibacterial and antifungal activity
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 18 |
| Scopus | 18 |
| Google Scholar | 19 |