Novel 1,2,4-triazole-maleamic acid derivatives: synthesis and evaluation as anticancer agents with carbonic anhydrase inhibitory activity
Yazarlar (11)
Michael Tapera
Erciyes Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Hüseyin Kekeçmuhammed
Erciyes Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Prof. Dr. Burak Tüzün Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Sevgi Durna Daştan Cumhuriyet Üniversitesi, Türkiye
Muhammed Safa Çelik
Cumhuriyet Üniversitesi, Türkiye
Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Parham Taslımı Bartin Üniversitesi, Türkiye
Doç. Dr. Taner Daştan Cumhuriyet Üniversitesi, Türkiye
Arş. Gör. Kübra Sena Baş Topcu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ercan Çaçan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Emin Sarıpınar Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2024 |
| Cilt / Sayı / Sayfa | 1313 / 1 / 138680–0 | DOI | 10.1016/j.molstruc.2024.138680 |
| Makale Linki | https://doi.org/10.1016/j.molstruc.2024.138680 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Hybrid compounds with 1,2,4-triazole ring and a hydrazone moiety were designed and synthesized by amine acylation of uncommon triaminogunidine derivatives using maleic anhydride. Synthesized compounds were characterized by various spectral techniques, including FTIR, 1H NMR, 13C NMR, and HRMS. Furthermore, the proposed structure of TM-2 was resolved by single-crystal X-ray analysis. The compounds were evaluated for their anticancer activity in vitro against the colon cancer cell line HCT116 and the ovarian cancer cell line A2780. Among them, some compounds, TM-3, TM-4, and TM-14, exhibited remarkable antiproliferative activity in the cell line A2780, with IC50 values of 6.11, 5.15, and 5.93 µM, respectively. Further investigation revealed that these compounds could inhibit cancerous cell growth by inducing an increase in caspase-3 activity. In addition, antioxidant capabilities, interaction with … |
| Anahtar Kelimeler |
| Computational studies | Cytotoxic activity | Enzyme inhibition | Hydrazole | Synthesis | Triazole |
Science Direct
Novel 1,2,4-triazole-maleamic acid derivatives: synthesis and evaluation as anticancer agents with carbonic anhydrase inhibitory activity
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 37 |
| Scopus | 38 |
| Google Scholar | 41 |