Spectral Characterization, Antioxidant, Antibacterial Activity, and Molecular Dynamics Simulation of a New Bis-benzimidazole Molecule, 1,5-Bis(1H-benzimidazol-2-yl)pentan-3-one
Yazarlar (5)
T. Karakurt
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kırşehir Ahi Evran Üniversitesi, Türkiye
A. Tavman
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
D. N. Çolak
Giresun Üniversitesi, Türkiye
Giresun Üniversitesi, Türkiye
A. A. Karaçelik
Giresun Üniversitesi, Türkiye
Giresun Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Russian Journal of Bioorganic Chemistry (Q3) | ||
| Dergi ISSN | 1068-1620 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2024 |
| Kabul Tarihi | 24-12-2023 | Yayınlanma Tarihi | 01-08-2024 |
| Cilt / Sayı / Sayfa | 50 / 4 / 1491–1511 | DOI | 10.1134/S1068162024040253 |
| Makale Linki | https://doi.org/10.1134/s1068162024040253 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Objective Bis-benzimidazoles are an interesting class of compounds due to their chelating characteristics, various biological effects, and fluorescence properties. Methods In this research, a new symmetric bis-benzimidazole derivative including a ketone group, 1,5-bis(1H-benzimidazol-2-yl)pentan-3-one (PBB), was synthesized and characterized. Antibacterial activity of PBB was tested against Gram-negative and Gram-positive bacteria. The total antioxidant capacity (as TEAC value) and free radical scavenging activity of (PBB) was determined by ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods. Molecular modeling methods have been conducted in order to study the relationship between electronic characteristics and antioxidant activity. Results and Discussion Molecular modelling techniques and approaches were used to ensure that (PBB) synthesized in this study … |
| Anahtar Kelimeler |
| antioxidant activity | bis-benzimidazole | computational study | molecular modelling | X-ray crystal |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |
| Google Scholar | 1 |