Phthalocyanine and azaphthalocyanines containing eugenol: synthesis, DNA interaction and comparison of lipase inhibition properties
Yazarlar (4)
Günay Kaya Kantar Recep Tayyip Erdoğan Üniversitesi, Türkiye
Prof. Dr. Özlem Faiz Recep Tayyip Erdoğan Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Selami Şaşmaz Recep Tayyip Erdoğan Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Chemical Sciences (Q3) | ||
| Dergi ISSN | 0974-3626 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2017 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 25-07-2017 |
| Cilt / Sayı / Sayfa | 129 / 8 / 1247–1256 | DOI | 10.1007/s12039-017-1320-4 |
| Makale Linki | http://link.springer.com/10.1007/s12039-017-1320-4 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Novel eugenol-substituted zinc(II) azaphthalocyanines (ZnAzaPcs) were synthesised and their lipase inhibition and DNA binding properties compared with phthalocyanines (Pcs) containing eugenol. This is the first study on lipase inhibition and DNA binding of Pcs and AzaPcs containing a pharmacophore group, such as eugenol. The novel ZnAzaPcs were characterised using a combination of FT-IR, NMR, NMR, UV–Vis, MS and elemental analysis. The crystal structures of two pyrazine compounds were also determined by the single crystal diffraction technique. This study showed that two phthalocyanines compounds (3a and 4a) could be potential lipase inhibitor agents due to greater hydrophobicity than other azaphtalocyanines. Compound 4a displayed lowest value. Non-intercalative binding to DNA was identified only for compound 2a.Graphical AbstractSYNOPSIS Novel eugenol-substituted zinc(II … |
| Anahtar Kelimeler |
| Azaphthalocyanine | DNA interaction | eugenoe | lipase inhibition | phthalocyanine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 12 |
| Google Scholar | 16 |