Exploration of UHPLC-ESI-QTOF-MS Profiles and the Neuroprotective, Antidiabetic, Antioxidant and Cytotoxic Effects of Extracts from Achillea maritima (L.) Ehrend. & Y.P.Guo (Asteraceae) Collected in Türkiye
 
Yazarlar (10)
Shakeel Ahmed
Selçuk Üniversitesi, Türkiye
Prof. Dr. Gokhan Zengin Selçuk Üniversitesi, Türkiye
Álvaro Fernández-Ochoa Universidad De Granada, Facultad De Ciencias, İspanya
Maria De La Luz Cádiz-Gurrea Universidad De Granada, Facultad De Ciencias, İspanya
Francisco Javier Leyva-Jiménez Universidad De Granada, Facultad De Ciencias, İspanya
Doç. Dr. Ömer ELKIRAN Sinop Üniversitesi, Türkiye
Prof. Dr. Ugur Cakilcioglu Munzur Üniversitesi, Türkiye
Bengusu H. Akgul
Selçuk Üniversitesi, Türkiye
Catarina G. Pereira
Universidade Do Algarve, Portekiz
Luísa Custódio Universidade Do Algarve, Portekiz
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Plant Foods for Human Nutrition (Q2)
Dergi ISSN 0921-9668 Dergi Bilgileri (2025)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 02-2025
Cilt / Sayı / Sayfa 80 / 1 / 1–8 DOI 10.1007/s11130-025-01314-x
Makale Linki https://doi.org/10.1007/s11130-025-01314-x
UAK Araştırma Alanları
Biyokimya
Özet
Abstract
The current study investigated the chemical composition, antioxidant activity, enzyme inhibition, and cytotoxic activities of extracts from Achillea maritima, a wild medicinal plant used for various therapeutic purposes. The antioxidant activities were assayed through different assays like DPPH, ABTS, CUPRAC, FRAP, and phosphomolybdenum, whereas in enzyme inhibition studies, cholinesterase, tyrosinase, α-amylase, and α-glucosidase were assayed. Cytotoxicity studies are conducted on S17, RAW, and HepG2 to assess its selectivity and effectiveness. Chemical profiling by UHPLC-ESI-QTOF-MS revealed multiple bioactive compounds in the extracts. Polar solvents (ethanol, ethanol/water, and water) resulted in high concentrations of phenolic acids as well as chlorogenic and caffeoylquinic acids, as well as flavonoids like vicenin and apigenin. On the other, the nonpolar (hexane extract) was rich in octadecatrienoic acid hydroperoxy and hydroxyoctadecatrienic acid. Among these, the water extract contained the highest phenolic content of 32.26 mg GAE/g, while the ethyl acetate extract was the richest in flavonoids, with 7.83 mg RE/g. In the antioxidant studies, the water and ethanol/water extracts consistently display the most potent activities, thus indicating their significant free radical scavenging and metal chelation abilities. The studies on enzyme inhibitions showed remarkable BChE inhibitory activities of the ethanol extract in 12.50 mg GALAE/g, thus showing potential in managing disease conditions related to cholinesterase. Tyrosinase inhibition was significant by the ethanol extract, presenting 55.59 mg KAE/g. The ethyl acetate extract exhibited the most potent inhibitory activity against α-amylase with 0.66 mmol ACAE/g, while ethanol extract showed significant inhibition of α-glucosidase with 4.35 ACAE/g. Cytotoxicity results showed that the water extract was most effective against the HepG2 cancer cell line by reducing cell viability to 38.4% at high doses while preserving low toxicity against normal cells, as observed by high viability percentages in S17 and RAW cell lines. These results highlight the usefulness of A. maritima extracts in nutraceutical, pharmaceutical, and cosmeceutical applications.
Anahtar Kelimeler
A. maritima | Antioxidant | Chemical profiling | Cytotoxicity | Enzyme inhibition
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 15
Scopus 13
Google Scholar 14
Exploration of UHPLC-ESI-QTOF-MS Profiles and the Neuroprotective, Antidiabetic, Antioxidant and Cytotoxic Effects of Extracts from Achillea maritima (L.) Ehrend. & Y.P.Guo (Asteraceae) Collected in Türkiye

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