A highly sensitive and selective electrochemical sensor based on computer-aided design of molecularly imprinted polymer for the determination of leflunomide
Yazarlar (6)
Prof. Dr. Ahmet Cetinkaya Ankara Üniversitesi, Türkiye
S. Irem Kaya
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
M. Emin Çorman Ankara Üniversitesi, Türkiye
Prof. Dr. Mustafa KARAKAYA Sinop Üniversitesi, Türkiye
Esen Bellur Atici Deva Holding A.S. R&D Center, Türkiye
Sibel A. Ozkan
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Microchemical Journal (Q1) | ||
| Dergi ISSN | 0026-265X Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2022 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-08-2022 |
| Cilt / Sayı / Sayfa | 179 / 1 / 1–8 | DOI | 10.1016/j.microc.2022.107496 |
| Makale Linki | http://dx.doi.org/10.1016/j.microc.2022.107496 | ||
| UAK Araştırma Alanları |
Atom, Molekül ve Lazer Fiziği
Spektroskopi
Optoelektronik
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| Özet |
| This study includes the electrochemical analysis of leflunomide (LEF), used in the treatment of rheumatoid arthritis, with a molecularly imprinted polymer (MIP) based sensor using different electroanalytical methods. In the design of MIPs, the choice of functional monomer is an important step in terms of the stability of the sensor. Based on the computational approach in this study, ortho-phenylenediamine (o-PD) was chosen as a functional monomer based on the comparison of interaction energies (ΔE) between LEF and monomers, aniline (ANI) was chosen as a platform to develop MIP-based sensor. Morphological characterization of the developed p(ANI-o-PD)@MIP/GCE sensor was performed using Raman spectroscopy, surface electron microscopy (SEM), contact angle measurements, and electrochemical techniques. Quantitative analysis of LEF was performed using differential pulse voltammetry. Results … |
| Anahtar Kelimeler |
| Drug analysis | Electrochemical determination | Leflunomide | Molecularly imprinted polymer | Voltammetry |
Science Direct
A highly sensitive and selective electrochemical sensor based on computer-aided design of molecularly imprinted polymer for the determination of leflunomide
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 29 |
| Scopus | 30 |
| Google Scholar | 34 |